Cardiac and skeletal muscle troponin I isoforms are encoded by a dispersed gene family on mouse Chromosomes 1 and 7 |
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| Authors: | J -L Guénet D Simon-Chazottes M Gravel K E M Hastings S Schiaffino |
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| Institution: | (1) Institut Pasteur de Paris, Unité de Génétique des mammifères, 25 rue du Docteur Roux, F-75724 Paris Cedex 15, France, FR;(2) Montreal Neurological Institute and Departments of Neurology/Neurosurgery and Biology, McGill University, Montreal, Québec, Canada, CA;(3) Department of Biomedical Sciences and CNR Unit for Muscle Biology and Physiopathology, University of Padova, 35121 Padova, Italy, IT |
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| Abstract: | We mapped the locations of the genes encoding the slow skeletal muscle, fast skeletal muscle, and cardiac isoforms of troponin
I (Tnni) in the mouse genome by interspecific hybrid backcross analysis of species-specific (C57BL/6 vs Mus spretus) restriction fragment length polymorphisms (RFLPs). The slow skeletal muscle troponin I locus (Tnni1) mapped to Chromosome (Chr) 1. The fast skeletal muscle troponin I locus (Tnni2), mapped to Chr 7, approximately 70 cM from the centromere. The cardiac troponin I locus (Tnni3) also mapped to Chr 7, approximately 5–10 cM from the centromere and unlinked to the fast skeletal muscle troponin I locus.
Thus, the troponin I gene family is dispersed in the mouse genome.
Received: 10 May 1995 / Accepted: 1 September 1995 |
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