The effect of oxidized cholesterol derivatives on the absorption and degradation of very low density beta-lipoproteins by human and rabbit hepatocytes

In our study the influence of oxidated cholesterol derivatives (7 alpha, 7 beta-oxicholesterol, 7-ketocholesterol, cholestene-3-one) on binding and degradation of beta-VLDL by human and rabbit hepatocytes was investigated. Cholesterol oxy derivatives inhibit the degradation of beta-VLDL in rabbit hepatocyte culture. There is no such effect with human hepatocytes. However beta-VLDL binding with human hepatocytes is significantly decreased under oxidated cholesterol derivatives influence.