Allelic polymorphisms and RFLP in the human immunoglobulin lambda light chain locus |
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| Authors: | Marie-Paule Lefranc Nathalie Pallarès Jean-Pol Frippiat |
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| Institution: | (1) Laboratoire d’ImmunoGénétique Moléculaire, LIGM, Université Montpellier II, UPR CNRS 1142, IGH, 141 rue de la Cardonille, F-34396 Montpellier cedex 5, France, FR;(2) Laboratoire de Biologie Expérimentale et d’Immunologie, Université Henri Poincaré, Nancy 1, Boulevard des Aiguillettes, BP 239, F-54506 Vandoeuvre-lès-Nancy cedex, France, e-mail: frippiat@scbiol.u-nancy.fr, Fax: +33-3-83912446, FR |
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| Abstract: | The organization of the human immunoglobulin lambda light chain locus (IGL) was recently described. This locus has been entirely
sequenced. To evaluate the extent of the genomic variability existing inside that locus, we compiled all the available sequences
of germline IGLV genes to find variants of Vλ sequences. We also looked for RFLP polymorphisms in a reputedly highly polymorphic
human population from eastern Senegal, and compiled all RFLP data previously published. Analysis of these data indicates that
IGLV alleles are frequent and increase the diversity of the lambda light chain repertoire in the human population. In contrast,
RFLP and polymorphism by insertion and/or deletion are limited in that locus. This observation reinforces our hypothesis that
the human IGL locus has undergone less evolutionary shuffling than the human kappa or heavy-chain loci.
Received: 23 December 1998 / Accepted: 1 March 1999 |
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