Binding affinities of gallotannin analogs with bovine serum albumin: ramifications for polyphenol-protein molecular recognition. |
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| Authors: | K S Feldman A Sambandam S T Lemon R B Nicewonger G S Long D F Battaglia S M Ensel M A Laci |
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| Affiliation: | Department of Chemistry, Pennsylvania State University, University Park 16802, USA. |
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| Abstract: | A series of gallotannin analogs were prepared by chemical synthesis, and their affinity for the test-case protein bovine serum albumin was measured by equilibrium dialysis. The structure/activity data obtained suggest that the naturally occurring gallotannins, in fact, do not represent the optimal protein recognition agents amongst polyphenolated templates. |
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