Identification of AGR2 protein, a novel potential cancer marker, using proteomics technologies |
| |
Authors: | Kovalev L I Shishkin S S Khasigov P Z Dzeranov N K Kazachenko A V Toropygin I Iu Mamykina S V |
| |
Abstract: | A comparative analysis of the proteins in prostate tissues of the patients operated for hyperplasia (n = 7) or cancer (n = 5) was performed aiming to search for protein diagnostic markers. Differences in several minor proteins were detected using two-dimensional electrophoresis according to O'Farrel; among them, an additional protein with a molecular weight of 19 kDa and an isoelectric point of 9.0 was observed in four of the cancer cases. Mass spectrometry allowed this protein to be identified as the androgen-induced secreted protein AGR2. The possibility of using AGR2 as a diagnostic marker of prostate cancer is discussed. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|