4,4-Disubstituted cyclohexylamine NK(1) receptor antagonists I |
| |
| Authors: | Elliott Jason M Castro Jose L Chicchi Gary G Cooper Laura C Dinnell Kevin Hollingworth Gregory J Ridgill Mark P Rycroft Wayne Kurtz Marc M Shaw Duncan E Swain Christopher J Tsao Kwei-Lan Yang Lihu |
| |
| Institution: | Department of Medicinal Chemistry, Merck Sharp & Dohme Research Laboratories, The Neuroscience Research Centre, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, UK. jason_elliot@merck.com |
| |
| Abstract: | A series of novel 4,4-disubstituted cyclohexylamine based NK(1) antagonists is described. The effect of changes to the C(1)-C(4) relative stereochemistry on the cyclohexane ring and replacements for the flexible linker are discussed, leading to the identification of compounds with high affinity and good in vivo duration of action. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
