Jellyfish mucin may have potential disease-modifying effects on osteoarthritis |
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| Authors: | Naoshi Ohta Masato Sato Kiminori Ushida Mami Kokubo Takayuki Baba Kayoko Taniguchi Makoto Urai Koji Kihira and Joji Mochida |
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| Institution: | (1) Department of Orthopaedic Surgery, Surgical Science, Tokai University School of Medicine, 143 Shimokasuya, Isehara Kanagawa, 259-1193, Japan;(2) Eco-Soft Materials Research Unit, Advanced Research Institute, Riken, 2-1 Hirosawa, Wako Saitama, 351-0198, Japan;(3) Jellyfish Research Laboratories, Inc, KSP E513 Sakado 3-2-1 Takatsu-ku, Kawasaki Kanagawa, 213-0012, Japan |
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| Abstract: | Background We aimed to study the effects of intra-articular injection of jellyfish mucin (qniumucin) on articular cartilage degeneration
in a model of osteoarthritis (OA) created in rabbit knees by resection of the anterior cruciate ligament. Qniumucin was extracted
from Aurelia aurita (moon jellyfish) and Stomolophus nomurai (Nomura's jellyfish) and purified by ion exchange chromatography. The OA model used 36 knees in 18 Japanese white rabbits.
Purified qniumucin extracts from S. nomurai or A. aurita were used at 1 mg/ml. Rabbits were divided into four groups: a control (C) group injected with saline; a hyaluronic acid
(HA)-only group (H group); two qniumucin-only groups (M groups); and two qniumucin + HA groups (MH groups). One milligram
of each solution was injected intra-articularly once a week for 5 consecutive weeks, starting from 4 weeks after surgery.
Ten weeks after surgery, the articular cartilage was evaluated macroscopically and histologically. |
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