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DNA polymorphism analysis of Brucella lipopolysaccharide genes reveals marked differences in O-polysaccharide biosynthetic genes between smooth and rough Brucella species and novel species-specific markers |
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| Authors: | Michel S Zygmunt José M Blasco Jean-Jacques Letesson Axel Cloeckaert and Ignacio Moriyón |
| Institution: | (1) INRA, UR1282, Infectiologie Animale et Sant? Publique, IASP, F-37380 Nouzilly, France;(2) Centro de Investigaci?n y Tecnolog?a Agroalimentaria (CITA) de Arag?n, Gobierno de Arag?n, Unidad de Sanidad Animal, Av Monta?ana, 930 50059 Zaragoza, Spain;(3) Laboratoire d'Immunologie et Microbiologie, Facult?s Universitaires, Notre-Dame de la Paix (FUNDP), Unit? de Recherche en Biologie Mol?culaire (URBM), Namur, Belgium;(4) Departamento de Microbiolog?a, Universidad de Navarra, Aptdo 177, 31080 Pamplona, Spain |
| Abstract: | BackgroundThe lipopolysaccharide is a major antigen and virulence factor of Brucella, an important bacterial pathogen. In smooth brucellae, lipopolysaccharide is made of lipid A-core oligosaccharide and N-formylperosamine O-polysaccharide. B. ovis and B. canis (rough species) lack the O-polysaccharide. |
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