A novel scoring schema for peptide identification by searching protein sequence databases using tandem mass spectrometry data |
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| Authors: | Zhuo Zhang Shiwei Sun Xiaopeng Zhu Suhua Chang Xiaofei Liu Chungong Yu Dongbo Bu Runsheng Chen |
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| Affiliation: | (1) Institute of Biophysics, Chinese Academy of Sciences, Beijing, P. R. China;(2) Institute of Computing Technology, Chinese Academy of Sciences, Beijing, P. R. China |
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| Abstract: | Background Tandem mass spectrometry (MS/MS) is a powerful tool for protein identification. Although great efforts have been made in scoring the correlation between tandem mass spectra and an amino acid sequence database, improvements could be made in three aspects, including characterization ofpeaks in spectra, adoption of effective scoring functions and access to thereliability of matching between peptides and spectra. |
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