Time scale and dimension analysis of a budding yeast cell cycle model |
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| Authors: | Anna Lovrics Attila Csikász-Nagy István Gy Zsély Judit Zádor Tamás Turányi and Béla Novák |
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| Institution: | (1) Laboratory for Chemical Kinetics, Institute of Chemistry, E?tv?s University (ELTE), P?zm?ny P. s?t?ny 1/A, H-1117 Budapest, Hungary;(2) Molecular Network Dynamics Research Group of the Hungarian Academy of Sciences and Budapest University of Technology and Economics, Gell?rt t?r 4, H-1521 Budapest, Hungary |
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| Abstract: | Background The progress through the eukaryotic cell division cycle is driven by an underlying molecular regulatory network. Cell cycle
progression can be considered as a series of irreversible transitions from one steady state to another in the correct order.
Although this view has been put forward some time ago, it has not been quantitatively proven yet. Bifurcation analysis of
a model for the budding yeast cell cycle has identified only two different steady states (one for G1 and one for mitosis)
using cell mass as a bifurcation parameter. By analyzing the same model, using different methods of dynamical systems theory,
we provide evidence for transitions among several different steady states during the budding yeast cell cycle. |
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