A novel surface protein of Trichomonas vaginalis is regulated independently by low iron and contact with vaginal epithelial cells |
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| Authors: | V Mundodi AS Kucknoor T-H Chang JF Alderete |
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| Affiliation: | (1) Department of Microbiology, University of Texas Health Science Center, San Antonio, TX, USA |
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| Abstract: | Background Trichomonosis caused by Trichomonas vaginalis is the number one, non-viral sexually transmitted disease (STD) that affects more than 250 million people worldwide. Immunoglobulin A (IgA) has been implicated in resistance to mucosal infections by pathogens. No reports are available of IgA-reactive proteins and the role, if any, of this class of antibody in the control of this STD. The availability of an IgA monoclonal antibody (mAb) immunoreactive to trichomonads by whole cell (WC)-ELISA prompted us to characterize the IgA-reactive protein of T. vaginalis. |
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