Identification of one peptide which inhibited infectivity of avian infectious bronchitis virus in vitro |
| |
Authors: | PENG Bo CHEN Hanyang TAN Yadi JIN Meilin CHEN Huanchun GUO Aizhen |
| |
Abstract: | Purified avian infectious bronchitis virus (IBV) was used to screen a random phage display peptide library. After the fourth
panning, 10 positive phages were sequenced and characterized. The phages specifically inhibited IBV infectivity in HeLa cells
and blocked IBV haemagglutination. One linear peptide “GSH HRH VHS PFV” from the positive phages with the highest neutralization
titer was synthesized and this peptide inhibited IBV infection in HeLa as well. The results may contribute to development
of antiviral therapeutics for IBV and studying the determinants for viral and cell interaction. |
| |
Keywords: | avian infectious bronchitis virus phage display peptides |
本文献已被 万方数据 SpringerLink 等数据库收录! |