Inhibition of bacterial growth, enterotoxin production, and spore outgrowth in strains of Bacillus cereus by bacteriocin AS-48 |
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Authors: | Abriouel Hikmate Maqueda Mercedes Gálvez Antonio Martínez-Bueno Manuel Valdivia Eva |
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Institution: | Departamento de Microbiología, Facultad de Ciencias, Universidad de Granada, C/Fuentenueva s/n, 18071 Grenada, Spain. |
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Abstract: | Bacteriocin AS-48 showed high bactericidal activity for mesophilic and psychrotrophic strains of Bacillus cereus over a broad pH range. AS-48 inhibition of the enterotoxin-producing strain LWL1 was enhanced by sodium nitrite, sodium lactate, and sodium chloride. The latter also enhanced AS-48 activity against strain CECT 131. Bacterial growth and enterotoxin production by strain LWL1 were completely inhibited at bacteriocin concentrations of 7.5 microg/ml. At subinhibitory bacteriocin concentrations, enterotoxin production decreased markedly and sporulation was delayed. Intact spores were resistant to AS-48 but became gradually sensitive to AS-48 during the course of germination. |
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