Heat adaptation from regular hot water immersion decreases proinflammatory responses,HSP70 expression,and physical heat stress |
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| Affiliation: | 1. Intensive Care Unit, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City 23142, Taiwan;2. School of Medicine, Tzu Chi University, Hualien 97004, Taiwan;3. Department of Nursing, Tzu Chi University of Science and Technology, Hualien 970, Taiwan;4. Department of Nursing, National Taichung University of Science and Technology, Taichung 404, Taiwan;5. Department of Nursing, St. Mary''s Medicine, Nursing and Management College, Yi-Lan 26644, Taiwan;6. Institute of Medical Sciences, Tzu Chi University, No. 701, Section 3, Zhongyang Rd., Hualien 97004, Taiwan;1. Graduate School of Bioresource and Bioenvironmental Science, Division for Experimental Natural Science, Faculty of Arts and Science, Kyushu University, Fukuoka 819-0395, Japan;2. Laboratory of Regulation in Metabolism and Behavior, Graduate School of Bioresource and Bioenvironmental Science, Kyushu University, Fukuoka 812-8581, Japan;1. Ph.D. candidate, Mechanical Engineering, Department of Mechanical Engineering, University of Birjand, Birjand, Iran;2. Associate Professor, Department of Mechanical Engineering, University of Birjand, Birjand, Iran;3. Assistant Professor, Department of Mechanical Engineering, University of Birjand, Birjand, Iran;4. Professor, Department of Mechanical Engineering, Tarbiat Modares University, Tehran, Iran;1. Key Laboratory of Freshwater Fisheries and Germplasm Resources Utilization, Ministry of Agriculture, Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi 214081, Jiangsu, China;2. Wuxi Fisheries College, Nanjing Agricultural University, Wuxi 214081, China;1. Faculty Saint-Jean, University of Alberta, Edmonton, Alberta, Canada, T6C 4G9;2. Dept. de Biologie, Laboratoire de Physiologie Animal Integrative, Université du Québec à Rimouski, Rimouski, Quebec, Canada, G5L 3A1 |
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| Abstract: | Hot-water immersion (HWI) is a type of thermal therapy for treating various diseases. In our study, the physiological responses to occasional and regular HWI have been explored. The rats were divided into a control group, occasional group (1D), and regular group (7D). The 1D and 7D groups received 42 °C during 15 mins HWI for 1 and 7 days, respectively. The blood samples were collected for proinflammatory cytokines examinations, the heart, liver and kidney were excised for subsequent IHC analysis to measure the level of heat shock protein 70 (HSP70). The results revealed that the body temperature increased significantly during HWI on Day 3 and significantly declined on Days 6 and 7. For the 7D group, body weight, heart rate, hematocrit, platelet, osmolarity, and lactate level were lower than those in the 1D group. Furthermore, the levels of granulocyte counts, tumor necrosis factor-α, and interleukin-6 were lower in the 7D group than in the 1D group. The induction of HSP70 in the 1D group was higher than in the other groups. Physiological responses to occasional HWI are disadvantageous because of heat stress. However, adaptation to heat from regular HWI resulted in decreased proinflammatory responses and physical heat stress. |
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| Keywords: | Hot-water immersion Heat shock protein Heat tolerance Heat stress Physiological response |
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