The small heat shock protein Hsp27: Present understanding and future prospects |
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| Affiliation: | 1. Paik Institute for Clinical Research, Inje University College of Medicine, 633-165 Gaegum-dong, Busanjin-gu, Busan 614-735, Republic of Korea;2. Department of Bioengineering, Hanyang University, 17 Haengdang-dong, Seongdong-gu, Seoul 133-791, Republic of Korea;3. Department of Molecular Science and Technology, Ajou University, San 5, Woncheon, Yeongtong, Suwon 443-749, Republic of Korea;1. Department of Cardiology, Fujian Provincial Clinical College, Fujian Medical University, Fuzhou, Fujian 350001, PR China;2. The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350001, PR China;1. College of Animal Science and Technology, Shandong Agricultural University, Taian, Shandong 271018, PR China;2. College of Life Sciences, Shandong Agricultural University, Taian, Shandong 271018, PR China |
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| Abstract: | Heat shock proteins are important for maintaining protein homeostasis and cell survival. Among different classes of highly conserved Hsps, low molecular weight Hsps (sHsps) have significant place, particularly Hsp27, whose role has been demonstrated in wide range of biological processes, including development, immunity, diseases and therapy. In this review, the structure and functions of Hsp27 and related genes, their role in different cellular processes as well as in stress tolerance, is highlighted. |
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| Keywords: | Hsp27 α-crystallin Apoptosis Development Biomarker |
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