New oligonucleotide analogues based on morpholine subunits joined by oxalyl diamide tether |
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| Authors: | Abramova Tatiana V Kassakin Marat F Lomzov Alexander A Pyshnyi Dmitrii V Silnikov Vladimir N |
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| Affiliation: | The Institute of Chemical Biology and Fundamental Medicine, Lavrent'ev Ave 8, Novosibirsk 630090, Russia. abramova@niboch.nsc.ru |
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| Abstract: | We report on the design, synthesis and some of the properties of the new oligonucleotide analogues based on morpholine nucleoside (MorB) subunits joined by an oxalyl diamide tether instead of a phosphate group. The synthetic strategy and oligomer design are optimized to easily obtain target substances without using protective groups. The dimers HOMorU-Ox-NHMorU, HOMorU-Ox-NHMorA, and uracil containing the hexamer HOMorU-(Ox-NHMorU)5 were synthesized. The structures of all substances were confirmed by 1H, 13C, NMR, and mass spectroscopy. Base stacking interactions in dimers were revealed by CD-spectra data. |
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| Keywords: | Oligonucleotide analogues Morpholine nucleosides Aminonucleosides |
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