The structure–function correlates of mammalian rod and cone photoreceptor mitochondria: observations and unanswered questions |
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Authors: | Guy A Perkins Mark H Ellisman Donald A Fox |
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Abstract: | Our previous work suggests that cone photoreceptor inner segment (CIS) mitochondria demand and produce more ATP than rods. The CISs utilize two complimentary strategies to increase ATP production: increase the absolute number of mitochondria and their cristae surface membrane area. In this treatise, we ask: How are crista junctions formed and regulated? Once formed, are there physical mechanisms that constrain their diameter? How are the constrictions in cristae regulated and is this key for cytochrome c release during apoptosis? What are their differences in rod and cone susceptibility to apoptotic cell death during calcium overload and oxidative stress? |
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Keywords: | Mitochondria Photoreceptors Cristae junction Apoptosis Calcium Lead |
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