Regulation of ion conductance in frog skin by isoproterenol |
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Authors: | M Granitzer W Nagel J Crabbé |
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Affiliation: | Département de Physiologie, Faculté de Médecine, U.C.L., Bruxelles, Belgium. |
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Abstract: | The effect of isoproterenol on apical and basolateral membrane conductance in principal cells of short-circuited frog skin was analyzed using microelectrodes. Isoproterenol (10(-6) mol/l) increased the apical membrane conductance in addition to stimulating Cl- conductive pathways outside the principal cells. The effect on apical Na+ channels explains the increase in amiloride sensitive short-circuit current. Basolateral membrane conductance increased only slightly. Steady-state I/V relationships of the basolateral membrane indicate that the inward rectification of basolateral membrane K+ channels was not altered. |
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