Study of a yeast mutant with modified mitochondrial translocation of adenine nucleotides |
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Authors: | P ?migáň Y Gbelská |
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Institution: | 1. Department of Biochemistry, Division of Organic Chemistry and Biochemistry, Faculty of Sciences, Komenshy University, Bratislava
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Abstract: | The effect of ethidium bromide on the growth of a yeast mutant with an impaired mitochrondrial translocation system of adenine nucleotides (op-1 mutant) was investigated. It was found that the op-1 mutant stops growing both under growing and non-growing conditions after treatment with ethidium bromide and that the growth cannot be restored by adding low-molecular compounds to the growth medium. It was the aim of the experiments to clarify whether the cessation of growth of the op-1 mutant after induction of the rho- mutation can be simulated by inhibitors phenotypically changing the mitochondrial function. It appears likely that the op-1 mutant stops growing only after the rho- mutation has been induced, because the phenotypic simulation of the rho- mutation does not lead the cessation of growth of the op-1 mutant. |
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