The synthesis of a novel thio-linked disaccharide of chondroitin as a potential inhibitor of polysaccharide lyases |
| |
| Authors: | Rye Carl S Withers Stephen G |
| |
| Affiliation: | Department of Chemistry, 2036 Main Mall, University of British Columbia, Vancouver, BC, Canada V6T 1Z1. |
| |
| Abstract: | A thio-linked disaccharide based on the structure of the glycosaminoglycan chondroitin was synthesized as a potential inhibitor of chondroitin AC lyase from Flavobacterium heparinum for structural analysis of the active site. Instead it was found to be a slow substrate, thereby demonstrating that lyases, in contrast to glycosidases, can cleave thioglycoside links between sugars. |
| |
| Keywords: | Glycosaminoglycan Polysaccharide lyase Flavobacterium heparinum Chondroitin Chondroitin AC |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
