Lysine sulfonamides as novel HIV-protease inhibitors: Nepsilon-acyl aromatic alpha-amino acids |
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| Authors: | Stranix Brent R Lavallée Jean-François Sévigny Guy Yelle Jocelyn Perron Valérie LeBerre Nicholas Herbart Dominik Wu Jinzi J |
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| Institution: | Ambrilia Biopharma Inc., 1000 chemin du Golf, Verdun, QC, Canada H3E 1H4. bstranix@ambrilia.com |
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| Abstract: | A series of lysine sulfonamide analogues bearing Nepsilon-acyl aromatic amino acids were synthesized using an efficient synthetic route. Evaluation of these novel protease inhibitors revealed compounds with high potency against wild-type and multiple-protease inhibitor-resistant HIV viruses. |
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