| 钙离子对乙酰胆碱受体通道脱敏的影响 |
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| 引用本文： | 郑煜芳,江波,吕义晟,李英姿,谢佐平.钙离子对乙酰胆碱受体通道脱敏的影响[J].生物物理学报,2000,16(1):59-65. |
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| 作者姓名： | 郑煜芳 江波 吕义晟 李英姿 谢佐平 |
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| 作者单位： | 清华大学生物科学与技术系,生物膜与膜生物工程国家重点实验室,北京100084 |
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| 摘 要： | Ｎ型乙酰胆碱受体通道的脱敏表现为通道开放概率的衰减，而通道开放时间和开放电流的变化水大，提示脱敏是全或无的，当「Ｃａ＾２＋」０＝１２．０ｍｍｏｌ／Ｌ时，脱敏５０％约用时１１．５分钟；「Ｃａ＾２＋」０＝０ｍｍｏｌ／Ｌ时，脱敏５０％药用时１．８分钟。证明在钙离子浓度较低的情况下，Ｎ型乙酰胆碱受体通道的脱敏较快，而下离子浓度较高时，通道脱敏慢，提示钙离子对通道从脱敏态到静息态的恢复有促进作用，并且对钙离
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| 关 键 词： | N型乙酰胆碱受体通道 脱敏 钙离子 |
| 文章编号： | 1000-6737(2000)0-0059-07 |
THE EFFECT OF CALCIUM ION ON NICOTINICACETYLCHOLINE RECEPTOR DESENSITIZATION |
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| ZHENG Yu-fang,JIANG Bo,LI Ying-zi,XIE Zuo-ping.THE EFFECT OF CALCIUM ION ON NICOTINICACETYLCHOLINE RECEPTOR DESENSITIZATION[J].Acta Biophysica Sinica,2000,16(1):59-65. |
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| Authors: | ZHENG Yu-fang JIANG Bo LI Ying-zi XIE Zuo-ping |
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| Abstract: | This study examined the effect of calcium on the desensitization of Nicotinic Acetylcholine Receptor(nAChR) on cultured Xenopus Laevis muscle cells. In cell-attached clamp recording, we found that desensitization is all or none. When the concentration of calcium is 12.0mmol/L, the half time of nAChR opening probability declination-T50 is 11.5minutes. When the concentration of calcium is 0mmol/L, T50 is about 1.8 minutes. These results show that calcium has an effect on the restoration of nAChR from desensitized states. We also studied the mechanism of the effect of Ca2 on nAChR channel desensitization. |
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| Keywords: | Nicotinic Acetylcholine Receptor(nAChR) Desensitization Calcium Patch clamp |
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