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Association of macrophage migration inhibitory factor (MIF) polymorphisms with risk of meningitis from Streptococcus pneumoniae |
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| Authors: | Doernberg Sarah Schaaf Bernhard Dalhoff Klaus Leng Lin Beitin Anna Quagliarello Vincent Bucala Richard |
| Affiliation: | a Department of Internal Medicine, Yale University School of Medicine, The Anlyan Center, S525, P.O. Box 208031, 300 Cedar Street, New Haven, CT 06520-8031, USA;b Medical Clinic III, University of Lübeck, 23538 Lübeck, Germany;c Division of Infectious Diseases, Yale University School of Medicine, Dana Building, 789 Howard Avenue, New Haven, CT 06519, USA |
| Abstract: | Macrophage migration inhibitory factor (MIF) is an upstream proinflammatory cytokine encoded by a functionally polymorphic locus. This study of 119 patients explored the potential relationship between MIF genotype and invasive Streptococcus pneumoniae infections. We observed an association between a high-expression MIF allele and occurrence of pneumococcal meningitis. |
| Keywords: | Macrophage migration inhibitory factor Cytokine Polymorphism Meningitis Inflammation |
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