Functional analysis of an intergenic non-coding sequence within mce1 operon of M.tuberculosis |
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| Authors: | Monika Joon Shipra Bhatia Rashmi Pasricha Mridula Bose Vani Brahmachari |
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| Affiliation: | (1) Dr B R Ambedkar Centre for Biomedical Research, University of Delhi, 110007 Delhi, India;(2) Vallabhbhai Patel Chest Institute, University of Delhi, 110007 Delhi, India |
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| Abstract: | Background The mce operons play an important role in the entry of M. tuberculosis into macrophages and non-phagocytic cells. Their non-redundant function as well as complex regulation is implied by the phenotype of mce mutants. Recently, mce1 operon was found to extend over 13 genes, fadD5 (Rv0166) being the first gene of the operon. The presence of a non-coding sequence of 200 base pairs between Rv0166 and Rv0167 is peculiar to mce1 among the four mce operons of M.tuberculosis. We have examined the function of this region. |
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