Patients with ovarian carcinoma excrete different altered levels of urine CD59, kininogen-1 and fragments of inter-alpha-trypsin inhibitor heavy chain H4 and albumin |
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| Authors: | Siti S Abdullah-Soheimi Boon-Kiong Lim Onn H Hashim Adawiyah S Shuib |
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| Institution: | 1.Institute of Biological Sciences, Faculty of Science,University of Malaya,Kuala Lumpur,Malaysia;2.Department of Obstetrics and Gynaecology, Faculty of Medicine,University of Malaya,Kuala Lumpur,Malaysia;3.Department of Molecular Medicine, Faculty of Medicine,University of Malaya,Kuala Lumpur,Malaysia;4.University of Malaya Centre for Proteomics Research, University of Malaya,Kuala Lumpur,Malaysia |
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| Abstract: | Background Diagnosis of ovarian carcinoma is in urgent need for new complementary biomarkers for early stage detection. Proteins that
are aberrantly excreted in the urine of cancer patients are excellent biomarker candidates for development of new noninvasive
protocol for early diagnosis and screening purposes. In the present study, urine samples from patients with ovarian carcinoma
were analysed by two-dimensional gel electrophoresis and the profiles generated were compared to those similarly obtained
from age-matched cancer negative women. |
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