Production of functionalized polyhydroxyalkanoates by genetically modified <Emphasis Type="Italic">Methylobacterium extorquens</Emphasis> strains |
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| Authors: | Philipp Höfer Young J Choi Michael J Osborne Carlos B Miguez Patrick Vermette Denis Groleau |
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| Institution: | 1.Microbial and Enzymatic Technology Group, Bioprocess Centre,Montréal,Canada;2.Laboratoire de Bioingénierie et de Biophysique de l'Université de Sherbrooke, Department of Chemical and Biotechnological EngineeringUniversité de Sherbrooke,2500 Boulevard de l'Université,Sherbrooke,Canada;3.Biophysics and Nuclear Magnetic Resonance, Institute for Research in Immunology and Cancer,Université de Montréal,Montréal,Canada;4.Oswaldo Cruz Foundation (FIOCRUZ), Bio-Manguinhos,Viral Vaccine Program,Rio de Janeiro/RJ,Brazil |
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| Abstract: | Background Methylotrophic (methanol-utilizing) bacteria offer great potential as cell factories in the production of numerous products
from biomass-derived methanol. Bio-methanol is essentially a non-food substrate, an advantage over sugar-utilizing cell factories.
Low-value products as well as fine chemicals and advanced materials are envisageable from methanol. For example, several methylotrophic
bacteria, including Methylobacterium extorquens, can produce large quantities of the biodegradable polyester polyhydroxybutyric acid (PHB), the best known polyhydroxyalkanoate
(PHA). With the purpose of producing second-generation PHAs with increased value, we have explored the feasibility of using
M. extorquens for producing functionalized PHAs containing C-C double bonds, thus, making them amenable to future chemical/biochemical
modifications for high value applications. |
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