Mitochondrial energy metabolism and redox state in dyslipidemias |
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| Authors: | Vercesi Anibal E Castilho Roger F Kowaltowski Alicia J Oliveira Helena C F |
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| Affiliation: | Departamento de Patologia Clínica, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, Brazil. anibal@unicamp.br |
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| Abstract: | Changes in mitochondrial function are intimately associated with metabolic diseases. Here, we review recent evidence relating alterations in mitochondrial energy metabolism, ion transport and redox state in hypercholesterolemia and hypertriglyceridemia. We focus mainly on changes in mitochondrial respiration, K(+) and Ca(2+) transport, reactive oxygen species generation and susceptibility to mitochondrial permeability transition. |
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