Forty Years of Clathrin‐coated Vesicles |
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Authors: | Margaret S. Robinson |
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Affiliation: | Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK |
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Abstract: | The purification of coated vesicles and the discovery of clathrin by Barbara Pearse in 1975 was a landmark in cell biology. Over the past 40 years, work from many labs has uncovered the molecular details of clathrin and its associated proteins, including how they assemble into a coated vesicle and how they select cargo. Unexpected connections have been found with signalling, development, neuronal transmission, infection, immunity and genetic disorders. But there are still a number of unanswered questions, including how clathrin‐mediated trafficking is regulated and how the machinery evolved. |
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Keywords: | adaptin adaptor dynamin endocytosis sorting signals trans‐Golgi network |
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