Bioactivity of synthetic C-terminal fragment of rat pancreastatin on endocrine pancreas |
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Authors: | A Funakoshi K Miyasaka K Kitani H Tamamura S Funakoshi H Yajima |
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Institution: | National Kyushu Cancer Center, Fukuoka, Japan. |
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Abstract: | A C-terminal fragment of rat pancreastatin, 26-residue peptide amide was synthesized by the Fmoc-based solid phase method and its biological activity was evaluated for the first time in the conscious rat. Rat pancreastatin inhibited glucose-stimulated insulin secretion and elevated blood glucose levels in a concentration of 10 nmol/kg/h. The relative molar potency of that of porcine is equivalent. This study suggests that the synthetic rat pancreastatin has a biological activity, and may play a physiological role in the endocrine pancreas. |
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