Effect of antifungal gels incorporated into a tissue conditioning material on the growth of Candida albicans |
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Authors: | Marta Radnai Rob Whiley Tim Friel Paul S Wright |
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Institution: | 1. Department of Prosthodontics, Faculty of Dentistry, University of Szeged, Szeged, Hungary;2. Clinical and Diagnostic Oral Sciences, Barts and The London School of Medicine and Dentistry, London, UK;3. Adult Oral Health, Barts and The London School of Medicine and Dentistry, London, UK |
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Abstract: | doi:10.1111/j.1741‐2358.2009.00337.x Effect of antifungal gels incorporated into a tissue conditioning material on the growth of Candida albicans Objective: The aim of this study was to examine the effectiveness of antifungal gels incorporated into a tissue conditioner which inhibits the growth of Candida albicans in vitro. Background: The release of drugs from relining materials has been demonstrated earlier. However, the incorporation of antifungal agents in gel form has not yet been studied. Materials and methods: Visco‐gel® tissue conditioner was prepared with chlorhexidine digluconate and miconazole in gel form in a concentration of 5, 10, 15, 20 and 25% by volume. Sample discs were prepared and placed on Sabouraud Dextrose Agar (SDA) plates which had been previously inoculated with C. albicans, and incubated aerobically at 37°C. To investigate antifungal activity over time, Visco‐gel discs containing 20%v/v miconazole were prepared and immersed in water for different time periods before being placed on SDA plates inoculated with C. albicans. Results: Chlorhexidine digluconate gel added to tissue conditioner had no inhibition effect on the growth of C. albicans. Incorporation of miconazole gave a dose‐related inhibitory effect on candidal growth. Immersion of the discs in water showed an inverse relationship between time of immersion and degree of inhibition. Conclusion: Miconazole added in gel form to Visco‐gel® had an inhibitory effect on the growth of C. albicans in vitro. |
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Keywords: | antifungal gel Candida albicans denture‐related stomatitis tissue conditioner |
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