Design,synthesis, biological evaluation,and molecular docking of chalcone derivatives as anti-inflammatory agents |
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Authors: | Jingfen Li Dong Li Yiming Xu Zhenbo Guo Xu Liu Hua Yang Lichuan Wu Lisheng Wang |
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Institution: | 1. Department of Life Science, Huzhou Teachers’ College, Huzhou 313000, People’s Republic of China;2. School of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, People’s Republic of China |
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Abstract: | In this study, two series of 35 new chalcone derivatives containing aryl-piperazine or aryl-sulfonyl-piperazine fragment were synthesized and their structures were characterized by 1H, 13C and ESI-MS. The in vivo and in vitro anti-inflammatory activities of target compounds were evaluated by using classical para-xylene-induced mice ear-swelling model and ELISA assays. Furthermore, docking studies were performed in COX-2 (4PH9). The in vivo anti-inflammatory assays indicated that most of the target compounds showed significant anti-inflammatory activities. Docking results revealed that the anti-inflammatory activities of compounds correlated with their docking results. Especially, compound 6o exhibited the most potent anti-inflammatory activity in vivo with the lowest docking score of ?17.4 kcal/mol and could significantly inhibit the release of LPS-induced IL-6 and TNF-α in a dose-dependent manner in vitro. |
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Keywords: | Inflammation Chalcone Derivatives Anti-inflammatory activity COX-2 |
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