Design,synthesis and biological evaluation of six dinuclear platinum(II) complexes |
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| Authors: | Congtao Yu Chuanzhu Gao Linkui Bai Qinghua Liu Zhuxin Zhang Yingjie Zhang Bo Yang Chunli Li Peng Dong Xiaojun Sun Yunxu Qian |
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| Institution: | 1. Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China;2. Department of Cardiovascular Medicine, Wenshan People''s Hospital, Wenshan 663000, China;3. Faculty of Materials Science and Engineering, Kunming University of Science and Technology, Kunming 650500, China;4. Engineering Laboratory for Advanced Battery and Material of Yunnan Province, Kunming 650500, China |
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| Abstract: | Six dinuclear platinum(II) complexes with a chiral tetradentate ligand, (1R,1′R,2R,2′R)-N1,N1′-(1,4-phenylenebis(methylene))dicyclohexane-1,2-diamine, have been designed, synthesized and characterized. In vitro cytotoxicity evaluation of these metal complexes against human A549, HCT-116, MCF-7 and HepG-2 cell lines have been carried out. All compounds showed antitumor activity to HepG-2, HCT-116 and A549. Particularly, compounds A1 and A2 exhibited significant better activity than other four compounds and A2 even showed comparable cytotoxicity to cisplatin against HepG-2 cell line. |
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| Keywords: | Dinuclear platinum(II) complexes Cytotoxicity Anticancer DNA insertion group |
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