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Reversible inhibition by interferon of the maturation of human peripheral blood monocytes to macrophages
Authors:S H Lee  L B Epstein
Affiliation:Cancer Research Institute and the Department of Pediatrics, University of California, San Francisco, California 94143 U.S.A.
Abstract:We demonstrated that interferon delays the maturation of human monocytes to macrophages in vitro as assessed by morphologic, histochemical, and biochemical parameters. After exposure to interferon, monocytes were slightly smaller, less stretched out, and had a delayed loss of granules with peroxidase positive reactivity, as compared with control, noninterferon-treated cells. Also, interferon prevented the increase of the specific activity of three lysosomal enzymes (β-galactosidase, β-glucuronidase, and β-N-acetylglucosaminidase) in the monocytes, and enzyme activities were 30–40% of that observed in untreated cells. Both human leukocyte and human fibroblast interferons were effective in delaying the maturation process. The effects of the interferon were species specific and reversible and were neutralized by antiinterferon serum. These studies describe a new nonantiviral effect of interferon, unique in that it involves the delay of maturation of cells in a system which is not associated with cell proliferation. Thus interferon could potentially effect host defense mechanisms and aspects of the immune response which are dependent on the maturation of monocytes to macrophages.
Keywords:Address reprint requests to Dr. Lois B. Epstein   Cancer Research Institute   Moffitt 1282   University of California   San Francisco   Calif. 94143.
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