Detection and study of the labile toxic factor of Proteus mirabilis]

The author studied the dynamics of toxin formation of the high- and low-virulent Pr. mirabilis strains. The high-virulent strain produced toxic substances of the exotoxin type detectable in 1-2-day broth cultures. Later the activity of the culture medium of both cultures under study was due to substances of the endotoxin type. By physico-chemical and immunobiological properties, and also by chemical composition of Pr. mirabilis "early toxin" was similar to the exoenterotoxins of enterobacteria. A principal possibility of concentration and purification of Pr. mirabilis "early toxin" with the use of ultrafiltration and gel-chromatography was demonstrated.