Changes in cell attachment by RSV transformation in rat liver epithelial cells. |
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| Authors: | K Mashima J Mizuguchi |
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| Affiliation: | Laboratory of Biochemistry, College of Science, Rikkyo (St. Paul's) University, Tokyo, Japan. |
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| Abstract: | BRL, a non-malignant rat liver epithelial-like cell line, possessed the ability to adhere through fibronectin to a solid substrate. Oncogenical transformation of these BRL cells with RSV induced a significant decrease in the fibronectin molecules in the extracellular matrix and reduction in its ability to adhere to fibronectin. The alpha 5 and beta 1 subunits of integrin (fibronectin receptor) were quantitatively diminished during RSV transformation in BRL cells. These results suggest that adhesive reduction of BRL cells to a substrate by RSV transformation may be caused by a decrease in cell surface fibronectin and fibronectin receptor molecules. |
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