| Abstract: | Thymic gangliosides GM3 and GD3 and LacCer incorporated into the membrane of the tumor target cell leukemia (YAC) increase its sensitivity to the membrane toxic action of spleen effectors. Unlike thymic gangliosides GD3, ganglioside GD3 of the brain origin substantially reduces tumor cell sensitivity to spleen effectors. Some other brain glycosphingolipids differing essentially in the structure of the carbohydrate part of the molecule exert the same action. It has been shown in model experiments with incorporation into the tumor cell membrane of brain ganglioside GD3 combined with thymic LacCer or with egg phosphatidylcholine that the increase in the sensitivity of the tumor cell membrane to spleen effectors is linked with a change in the properties of the lipid membrane matrix under the effect of unsaturated fatty acids (e.g. in experiments with phosphatidylcholine). It follows from the data presented that the capability of influencing the sensitivity of tumor cells to natural spleen effectors largely depends on the differences in the structure of the cearamide part of brain and thymic GD3. |
