GABAA Receptors in the Pars Compacta and GABAB Receptors in the Pars Reticulata of Rat Substantia Nigra Modulate the Striatal Dopamine Release |
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| Authors: | Balon Norbert Kriem Badreddine Weiss Michel Rostain Jean-Claude |
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| Institution: | (1) Laboratoire de Physiopathologie et Action Thérapeutique des Gaz sous Pression, Faculté de Médecine Nord, Université de la Méditerranée et IMNSSA, E.A. 3280, IFR Jean Roche, 13916 Marseille cedex 20, France |
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| Abstract: | The nigral GABAergic regulation of striatal dopamine release was investigated using voltammetry in freely moving rats. The local administration of muscimol (1 nM) in the substantia nigra pars compacta, but not in the substantia nigra pars reticulata, increased the striatal dopamine release. In contrast, the administration of baclofen (10 nM) in the substantia nigra pars reticulata, but not in the substantia nigra pars compacta, produced a decrease of the striatal dopamine release. Opposite effects were respectively observed after administration of GABAA and GABAB antagonists. These data lead us to suggest a differential presynaptic GABAergic control of the dopaminergic neurotransmission through GABAA receptors in the substantia nigra pars compacta, and GABAB receptors in the substantia nigra pars reticulata. |
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| Keywords: | 5-Aminovaleric acid baclofen bicuculline muscimol voltammetry |
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