Inhibitors of the bacterial cell wall biosynthesis enzyme MurC |
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| Authors: | Reck F Marmor S Fisher S Wuonola M A |
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| Affiliation: | Chemistry, Infection Discovery, AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, MA 02451, USA. |
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| Abstract: | A series of phosphinate transition-state analogues of the L-alanine adding enzyme (MurC) of bacterial peptidoglycan biosynthesis was prepared and tested as inhibitors of the Escherichia coli enzyme. Compound 4 was identified as a potent inhibitor of MurC from Escherichia coli with an IC(50) of 49nM. |
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