The role of curcumin on intestinal oxidative stress,cell proliferation and apoptosis after ischemia/reperfusion injury in rats |
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Authors: | Ahmet Fikret Yucel Mehmet Kanter Ahmet Pergel Mustafa Erboga Ahmet Guzel |
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Affiliation: | (1) Department of Surgery, Faculty of Medicine, Rize University, Rize, Turkey;(2) Department of Histology and Embryology, Faculty of Medicine, Trakya University, 22030 Edirne, Turkey;(3) Department of Pediatrics, Faculty of Medicine, Ondokuz Mayis University, Samsun, Turkey |
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Abstract: | The aim of this study was to demonstrate the role of curcumin on oxidative stress, cell proliferation and apoptosis in the
rat intestinal mucosa after ischemia/reperfusion (I/R). A total of 30 male Wistar albino rats were divided into three groups:
sham, I/R and I/R+ curcumin; each group contain 10 animals. Sham group animals underwent laparotomy without I/R injury. After
I/R groups animals underwent laparotomy, 1 h of superior mesenteric artery ligation were followed by 1 h of reperfusion. In
the curcumin group, 3 days before I/R, curcumin (100 mg/kg) was administered by gastric gavage. All animals were sacrificed
at the end of reperfusion and intestinal tissues samples were obtained for biochemical and histopathological investigation
in all groups. Curcumin treatment significantly decreased the elevated tissue malondialdehyde levels and increased of reduced
superoxide dismutase, and glutathione peroxidase enzyme activities in intestinal tissues samples. I/R caused severe histopathological
injury including mucosal erosions and villous congestion and hemorrhage. Curcumin treatment significantly attenuated the severity
of intestinal I/R injury, with inhibiting of I/R-induced apoptosis and cell proliferation. These results suggest that curcumin
treatment has a protective effect against intestinal damage induced by intestinal I/R. This protective effect is possibly
due to its ability to inhibit I/R-induced oxidative stress, apoptosis and cell proliferation. |
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