Unique subpopulations of CD56+ NK and NK-T peripheral blood lymphocytes identified by chemokine receptor expression repertoire |
| |
Authors: | Campbell J J Qin S Unutmaz D Soler D Murphy K E Hodge M R Wu L Butcher E C |
| |
Institution: | Joint Program in Transfusion Medicine, Children's Hospital, 300 Longwood Avenue, Room BD-401, Boston, MA 02115. campbell_ja@tch.harvard.edu |
| |
Abstract: | CD56, an adhesion molecule closely related to neural cell adhesion molecule, is an immunophenotypic marker for several unique populations of PBLS: Although CD56(+) cells derive from multiple lymphocyte lineages, they share a role in immunosurveillance and antitumor responses. We have studied the chemokine receptor expression patterns and functional migratory responses of three distinct CD56(+) populations from human peripheral blood. NK-T cells were found to differ greatly from NK cells, and CD16(+) NK cells from CD16(-) NK cells. CD16(+) NK cells were the predominant population responding to IL-8 and fractalkine, whereas NK-T cells were the predominant population responding to the CCR5 ligand macrophage-inflammatory protein-1beta. CD16(-) NK cells were the only CD56(+) population that uniformly expressed trafficking molecules necessary for homing into secondary lymphoid organs through high endothelial venule. These findings describe a diverse population of cells that may have trafficking patterns entirely different from each other, and from other lymphocyte types. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|