Residue-Resolved Stability of Full-Consensus Ankyrin Repeat Proteins Probed by NMR期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Residue-Resolved Stability of Full-Consensus Ankyrin Repeat Proteins Probed by NMR

Authors:	Svava K Wetzel Christina Ewald Giovanni Settanni Andreas Plückthun Oliver Zerbe

Institution:	¹ Institute of Biochemistry, University of Zürich, CH-8057 Zürich, Switzerland ² Institute of Organic Chemistry, University of Zürich, CH-8057 Zürich, Switzerland ³ MRC Centre for Protein Engineering, Cambridge CB2 0QH, UK

Abstract:

Keywords:	DARPin designed ankyrin repeat protein AR ankyrin repeat MD molecular dynamics H/D hydrogen/deuterium MEXICO measurement of fast proton exchange rates in isotopically labeled compounds PRE paramagnetic relaxation enhancement HSQC heteronuclear single quantum coherence NOE nuclear Overhauser enhancement MTSL 1-oxyl-2 2 5 5-tetramethyl-Δ3-pyrroline-3-methyl)mercaptyl MalNEt N-ethyl-maleimide PF protection factor
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