Corticotropin-releasing hormone, its binding protein and receptors in human cervical tissue at preterm and term labor in comparison to non-pregnant state |
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Authors: | Aurelija Klimaviciute Jacopo Calciolari Emma Bertucci Susanne Abelin-Tornblöm Ylva Stjernholm-Vladic Birgitta Byström Felice Petraglia Gunvor Ekman-Ordeberg |
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Affiliation: | (1) Dept. of Woman and Child Health, Karolinska Institute, Stockholm, Sweden;(2) Dept. of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy |
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Abstract: | Background Preterm birth is still the leading cause of neonatal morbidity and mortality. The level of corticotropin-releasing hormone (CRH) is known to be significantly elevated in the maternal plasma at preterm birth. Although, CRH, CRH-binding protein (CRH-BP), CRH-receptor 1 (CRH-R1) and CRH-R2 have been identified both at mRNA and protein level in human placenta, deciduas, fetal membranes, endometrium and myometrium, no corresponding information is yet available on cervix. Thus, the aim of this study was to compare the levels of the mRNA species coding for CRH, CRH-BP, CRH-R1 and CRH-R2 in human cervical tissue and myometrium at preterm and term labor and not in labor as well as in the non-pregnant state, and to localize the corresponding proteins employing immunohistochemical analysis. |
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