| 天门冬水提液及其纳米中药对衰老模型小鼠NOS、NO、LPF的影响 |
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| 引用本文： | 赵玉佳,孟祥丽,李秀玲,曲凤玉. 天门冬水提液及其纳米中药对衰老模型小鼠NOS、NO、LPF的影响[J]. 中国野生植物资源, 2005, 24(3): 49-51 |
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| 作者姓名： | 赵玉佳 孟祥丽 李秀玲 曲凤玉 |
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| 作者单位： | 佳木斯大学化学与药学院,黑龙江,佳木斯,154007 |
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| 摘 要： | 目的:探讨中药天门冬及其纳米化后对D-半乳糖衰老模型小鼠血清和肝的抗氧化作用.方法:采用D-半乳糖致衰老小鼠分别ig相同剂量的天门冬水提液及其纳米中药15 d,测定衰老小鼠血清中一氧化氮合酶(NOS)的活性,一氧化氮(NO)含量及肝组织中脂褐素(LP下)的含量.结果:天门冬水提波及其纳米中药均能显著增强小鼠血清中NOS的活性(P＜0.01),提高N0含量(P＜0.05),降低LPF含量(P＜0.05),且纳米中药的药效强于天门冬水提液的药效(P＜0.05).结论:天门冬水提液及其纳米中药均有抗氧化作用,且纳米中药比水提液药效更好.
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| 关 键 词： | 天门冬 抗氧化 纳米中药 |
| 修稿时间： | 2004-07-18 |
Influence of Radix Asparagi Nano- pharmaceutics on NOS, NO, LPF of Senile Mice |
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| Zhao Yujia,Meng Xiangli,Li Xiuling,Qu Fengyu. Influence of Radix Asparagi Nano- pharmaceutics on NOS, NO, LPF of Senile Mice[J]. Chinese Wild Plant Resources, 2005, 24(3): 49-51 |
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| Authors: | Zhao Yujia Meng Xiangli Li Xiuling Qu Fengyu |
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| Abstract: | Object:To study the effect of antioxidant of radix asparagi water extract and radix asparagi Nano-Pharmaceutics on serum and liver.Methods:D-galactose-induced model senile mice were used.Given same dose of radix asparagi water extract and radix asparagi Nano-Pharmaceutics for 15 days,the activity of nitric oxide synthetics enzyme (NOS),the level of nitric oxide (NO) in serum and lipofuscin (LPF) in liver were measured.Results:Compared with model group,the given medicine group enhanced the activity of NOS(P<0.01),increased the level of NO(P<0.05) and decrease the content of LPF(P<0.05).Furthermore,the effect of radix asparagi Nano-Pharmaceutics was better than radix asparagi water extract (P<0.05).Conclusion:Both the water extract and Nano-Pharmaceutics of radix asparagi have the effect of antiaging,meanwhile,the radix asparagi Nano-Pharmaceutics has better effect than water extract of radix asparagi. |
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| Keywords: | NOS NO LPF |
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