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A new antioxidant compound H-290/51 attenuates heat shock protein (HSP 72 kD) response, edema and cell injury following acute heat exposure. An experimental study using light and electron microscopy in the rat |
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| Authors: | Susanne Hedlund, Hari Shanker Sharma, Per-Ove Sj quist,Jan Westman |
| Affiliation: | a Laboratory of Neuroanatomy, Department of Medical Cell Biology, Biomedical Centre, Uppsala University, Uppsala, Sweden b Pharmacology CV, Astra Hässle, Mölndal, Sweden |
| Abstract: | Rats exposed to 4 h heat stress at 38°C exhibited upregulation of heat shock protein (HSP 72 kD) expression in several brain regions associated with brain edema and cell injury. Pretreatment with a new anti-oxidant compound H-290/51 (50 mg/kg, per os, 30 min before stress) significantly attenuated HSP expression, brain edema and cell injury. These results suggest that oxidative stress associated with brain edema plays important roles in HSP expression, not reported earlier. |
| Keywords: | Heat stress HSP 72 kD Oxidative stress Hyperthermia Neuronal injury Edema H-290/51 Immunohistochemistry |
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