1. ACRF Stem Cells and Cancer Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia;2. Bioinformatics Division, The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia;3. Department of Medical Biology, The University of Melbourne, Parkville, VIC 3050, Australia;4. Department of Medicine, The University of Melbourne, Parkville, VIC 3050, Australia;5. Department of Computing and Information Systems, The University of Melbourne, Parkville, VIC 3050, Australia;6. Department of Mathematics and Statistics, The University of Melbourne, Parkville, VIC 3050, Australia;7. Department of Medical Oncology, The Royal Melbourne Hospital, Grattan Street, Parkville, VIC 3050, Australia
Abstract:
Download : Download full-size image
Highlights? The mammary epigenome is highly sensitive to steroid hormones at specific developmental stages ? Ezh2 links hormonal cues to changes in chromatin structure and gene expression ? Progesterone is a key in vivo regulator of Ezh2 ? Hormone-induced chromatin changes likely play a role in the initiation of breast cancer
