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Influenza A Virus Utilizes Suboptimal Splicing to Coordinate the Timing of Infection
Authors:Mark A Chua  Sonja Schmid  Jasmine T Perez  Ryan A Langlois  Benjamin R tenOever
Institution:1. Microbiology Graduate School Training Program, Mount Sinai School of Medicine, New York, NY 10029, USA;2. Department of Microbiology, Mount Sinai School of Medicine, New York, NY 10029, USA;3. Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine, New York, NY 10029, USA
Abstract:
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  • Highlights? Demonstrates how a bicistronic gene can influence biological circuits ? Characterizes potency of innate immune antagonism in vivo ? Demonstrates how host factors can contribute to the timing of a virus life cycle ? Implicates NEP accumulation in the timing of IAV infection
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