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Forgetting in C. elegans Is Accelerated by Neuronal Communication via the TIR-1/JNK-1 Pathway
Authors:Akitoshi Inoue  Etsuko Sawatari  Naoki Hisamoto  Tomohiro Kitazono  Takayuki Teramoto  Manabi Fujiwara  Kunihiro Matsumoto  Takeshi Ishihara
Institution:1. Department of Biology, Faculty of Sciences, Kyushu University, Higashi-ku, Fukuoka 812-8581, Japan;2. Graduate School of Systems Life Sciences, Kyushu University, Higashi-ku, Fukuoka 812-8581, Japan;3. Faculty of Arts and Science, Kyushu University, Nishi-ku, Fukuoka 819-0395, Japan;4. Department of Molecular Biology, Graduate School of Science, Nagoya University, Chikusa-ku, Nagoya 464-8602, Japan
Abstract:
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  • Highlights? Food signals actively regulate forgetting of olfactory adaptation ? TIR-1/JNK-1 pathway accelerates forgetting of adaptation and of associative learning ? Response to diacetyl in AWA neurons is diminished after exposure to diacetyl ? Neurosecretion from AWC neurons is important for the acceleration of forgetting
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