1. Howard Hughes Medical Institute, Boston University, Boston, MA 02215, USA;2. Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA;3. Center for BioDynamics, Boston University, Boston, MA 02215, USA;4. Boston University School of Medicine, Boston, MA 02118, USA;5. Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA
Abstract:
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Highlights? Fungicide-dependent reactive oxygen species production leads to fungal cellular death ? The TCA, ETC, and RAS/PKA pathways are involved in fungicide-induced cellular death ? Antifungals elevate mitochondrial activity, the AMP/ATP ratio, and sugar production ? DNA damage plays an important role in fungicide-induced cellular death