1. Center for Regenerative Medicine in Barcelona, Barcelona 08003, Spain;2. Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
Abstract:
Highlights? Macrohistone variants are regulated during reprogramming and differentiation ? The levels of macrohistone variants modulate the efficiency of reprogramming ? MacroH2A.1 occupies pluripotency and differentiation genes in keratinocytes ? MacroH2A.1 occupancy prevents the gain of H3K4me2 during reprogramming