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Macrohistone Variants Preserve Cell Identity by Preventing the Gain of H3K4me2 during Reprogramming to Pluripotency
Authors:María   J. Barrero,Borja Sese,Bernd Kuebler,Josipa Bilic,Stephanie Boue,Mercè Martí,Juan   Carlos Izpisua   Belmonte
Affiliation:1. Center for Regenerative Medicine in Barcelona, Barcelona 08003, Spain;2. Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA
Abstract:
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  • Highlights? Macrohistone variants are regulated during reprogramming and differentiation ? The levels of macrohistone variants modulate the efficiency of reprogramming ? MacroH2A.1 occupies pluripotency and differentiation genes in keratinocytes ? MacroH2A.1 occupancy prevents the gain of H3K4me2 during reprogramming
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