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Macrohistone Variants Preserve Cell Identity by Preventing the Gain of H3K4me2 during Reprogramming to Pluripotency

Authors:	María J Barrero Borja Sese Bernd Kuebler Josipa Bilic Stephanie Boue Mercè Martí Juan Carlos Izpisua Belmonte

Institution:	1. Center for Regenerative Medicine in Barcelona, Barcelona 08003, Spain;2. Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA

Abstract:	Download : Download full-size image Highlights? Macrohistone variants are regulated during reprogramming and differentiation ? The levels of macrohistone variants modulate the efficiency of reprogramming ? MacroH2A.1 occupies pluripotency and differentiation genes in keratinocytes ? MacroH2A.1 occupancy prevents the gain of H3K4me2 during reprogramming

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